The complex relationship of 1 gene duplication and
نویسندگان
چکیده
In yeast and worm, duplicate genes overlap in 7 function so that deleting one of a pair from the 8 genome is less likely to be lethal than deleting a 9 singleton gene. By contrast, previous analyses 10 showed that mouse duplicate genes were as 11 essential as singletons. We show that the 12 relationship between gene duplication and 13 essentiality is complex in multicellular organisms, 14 with developmental genes and genes that were 15 duplicated by whole genome duplication being 16 more essential than other duplicated genes. 17
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